Name | methyl L-argininate dihydrochloride |
Synonyms | H-Arg-OMe·2HCl H-ARG-OME 2HCL ARGININE-OME 2 HCL L-Arginine Methyl Ester 2HCl L-ARGININE METHYL ESTER DIHCL L-arginine methyl ester dihcl methyl L-argininate dihydrochloride Methyl L-argininate dihydrochloride L-ARGININE METHYL ESTER HYDROCHLORIDE L-ARGININE METHYL ESTER DIHYDROCHLORIDE L-Arginine methyl ester dihydrochloride L-Arginine, methyl ester, dihydrochloride L-ARGININE METHYL ESTER DIHYDROCHLORIDE SALT (4S)-N~1~-(diaminomethylidene)-5-methoxy-5-oxopentane-1,4-diaminium |
CAS | 26340-89-6 |
EINECS | 247-622-0 |
InChI | InChI=1/C7H16N4O2/c1-13-6(12)5(8)3-2-4-11-7(9)10/h5H,2-4,8H2,1H3,(H4,9,10,11)/p+2/t5-/m0/s1 |
Molecular Formula | C7H18Cl2N4O2 |
Molar Mass | 261.15 |
Melting Point | ~190°C (dec.) |
Boling Point | 329.9°C at 760 mmHg |
Specific Rotation(α) | 20 º (c=2.5 CH3OH) |
Flash Point | 153.3°C |
Solubility | soluble in Methanol |
Vapor Presure | 0.000172mmHg at 25°C |
Appearance | Crystalline Powder |
Color | White to off-white |
BRN | 4159929 |
Storage Condition | Inert atmosphere,Room Temperature |
Sensitive | Hygroscopic |
Refractive Index | 21 ° (C=2.5, MeOH) |
MDL | MFCD00038948 |
Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
WGK Germany | 3 |
TSCA | Yes |
HS Code | 29252900 |
Reference Show more | Zhang Xingying, Lin Yameng, Qu Yuan, et al. Investigation of transdermal penetration enhancing activity of amino acid ester ionic liquids [J]. Chinese Journal of Pharmaceutical Industry, 2017, 29 (4). |
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
Application | L-arginine methyl ester dihydrochloride is abbreviated as Arg · Oet · 2HCl, which can be obtained by esterification of L-arginine hydrochloride with methanol. L-arginine methyl ester dihydrochloride can be used to prepare arginine derivative Fmoc-Arg(Pbf)-OH. |
preparation | a1. Add 100L of anhydrous ethanol into a pre-dried 300L reaction kettle, cool the temperature to -5 ~-10 ℃ through ice brine, and add 13L of dichlorosulfoxide dropwise. B1. Add 21.5kg of D-type Arg.HCl, turn off the ice brine, and naturally raise the temperature to room temperature for 24 hours. c1. The reaction was heated to 35 ℃, TLC point plate followed the reaction, and the reaction ended about 48h. D1. Concentration: After the reaction is over, the oil-like L-arginine methyl ester dihydrochloride intermediate is concentrated under reduced pressure. |